Ideally, patients should be within 30 pounds of their ideal body weight and be healthy and able to move freely for positioning and hold still for 45 minutes at a time. This is not a weight loss treatment. Any patient who has cryoglobulinemia, cold agglutinin disease or paroxysmal cold hemoglobinuria is not a candidate. Paradoxical adipose hyperplasia “PAH” has been reported as a rare adverse event after cryolipolysis. In this condition, the treated area becomes larger rather than smaller in the weeks after the procedure, leaving a “painless, visibly enlarged, firm, well-demarcated mass” under the skin, which does need surgery to correct. It is reported to happen in about 1 in 20,000 patients.